An antibody with Fab-constant domains exchanged for a pair of C(H)3 domains

We have designed a complete antibody-like construct where the C(H)1 and C(κ) domains are exchanged for a pair of the C(H)3 domains and efficient pairing of the heavy and light variable domain is achieved using “Knobs-into-Holes” strategy. This construct, composed of only naturally occurring immunogl...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Wozniak-Knopp, Gordana, Stadlmayr, Gerhard, Perthold, Jan Walther, Stadlbauer, Katharina, Gotsmy, Mathias, Becker, Stefan, Rüker, Florian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5891013/
https://ncbi.nlm.nih.gov/pubmed/29630643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195442
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