A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling

Intracellular signaling through the T cell receptor (TCR) is essential for T cell development and function. Proper TCR signaling requires the sequential activities of Lck and ZAP-70 kinases, which result in the phosphorylation of tyrosine residues located in the CD3 ITAMs and the LAT adaptor, respec...

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Published in:Cells
Main Authors: Vico-Barranco, Inmaculada, Arbulo-Echevarria, Mikel M., Serrano-García, Isabel, Pérez-Linaza, Alba, Miranda-Sayago, José M., Miazek, Arkadiusz, Narbona-Sánchez, Isaac, Aguado, Enrique
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7915312/
https://ncbi.nlm.nih.gov/pubmed/33562083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020343
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