A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling

The adaptor protein linker for activation of T cells (LAT) has an essential role transducing activatory intracellular signals coming from the TCR/CD3 complex. Previous reports have shown that upon T-cell activation, LAT interacts with the tyrosine kinase Lck, leading to the inhibition of its kinase...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Arbulo-Echevarria, Mikel M., Narbona-Sánchez, Isaac, Fernandez-Ponce, Cecilia M., Vico-Barranco, Inmaculada, Rueda-Ygueravide, Mª Dolores, Dustin, Michael L., Miazek, Arkadiusz, Duran-Ruiz, Mª Carmen, García-Cózar, Francisco, Aguado, Enrique
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801411/
https://ncbi.nlm.nih.gov/pubmed/29456532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00115
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