Promoter-proximal CTCF-binding promotes long-range-enhancer dependent gene activation

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drives the formation of chromatin loops and topologically associating domains, but its role in gene regulation has not been fully defined. Here, we investigated the effects of acute CTCF loss on chromatin architecture and tra...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Kubo, Naoki, Ishii, Haruhiko, Xiong, Xiong, Bianco, Simona, Meitinger, Franz, Hu, Rong, Hocker, James D., Conte, Mattia, Gorkin, David, Yu, Miao, Li, Bin, Dixon, Jesse R., Hu, Ming, Nicodemi, Mario, Zhao, Huimin, Ren, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913465/
https://ncbi.nlm.nih.gov/pubmed/33398174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00539-5
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