Promoter-proximal CTCF-binding promotes long-range-enhancer dependent gene activation

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drives the formation of chromatin loops and topologically associating domains, but its role in gene regulation has not been fully defined. Here, we investigated the effects of acute CTCF loss on chromatin architecture and tra...

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Veröffentlicht in:Nat Struct Mol Biol
Hauptverfasser: Kubo, Naoki, Ishii, Haruhiko, Xiong, Xiong, Bianco, Simona, Meitinger, Franz, Hu, Rong, Hocker, James D., Conte, Mattia, Gorkin, David, Yu, Miao, Li, Bin, Dixon, Jesse R., Hu, Ming, Nicodemi, Mario, Zhao, Huimin, Ren, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913465/
https://ncbi.nlm.nih.gov/pubmed/33398174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00539-5
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