CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

CTCF/cohesin play a central role in insulator function and higher-order chromatin organization of mammalian genomes. Recent studies identified a correlation between the orientation of CTCF-binding sites (CBSs) and chromatin loops. To test the functional significance of this observation, we combined...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Guo, Ya, Xu, Quan, Canzio, Daniele, Shou, Jia, Li, Jinhuan, Gorkin, David U., Jung, Inkyung, Wu, Haiyang, Zhai, Yanan, Tang, Yuanxiao, Lu, Yichao, Wu, Yonghu, Jia, Zhilian, Li, Wei, Zhang, Michael Q., Ren, Bing, Krainer, Adrian R., Maniatis, Tom, Wu, Qiang
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642453/
https://ncbi.nlm.nih.gov/pubmed/26276636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.038
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