CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

CTCF/cohesin play a central role in insulator function and higher-order chromatin organization of mammalian genomes. Recent studies identified a correlation between the orientation of CTCF-binding sites (CBSs) and chromatin loops. To test the functional significance of this observation, we combined...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Guo, Ya, Xu, Quan, Canzio, Daniele, Shou, Jia, Li, Jinhuan, Gorkin, David U., Jung, Inkyung, Wu, Haiyang, Zhai, Yanan, Tang, Yuanxiao, Lu, Yichao, Wu, Yonghu, Jia, Zhilian, Li, Wei, Zhang, Michael Q., Ren, Bing, Krainer, Adrian R., Maniatis, Tom, Wu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642453/
https://ncbi.nlm.nih.gov/pubmed/26276636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.038
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados