Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9

The human genome contains millions of DNA regulatory elements and a large number of gene clusters, most of which have not been tested experimentally. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease 9 (Cas9) programed with a synthetic single-guide RNA...

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Publicado no:J Mol Cell Biol
Main Authors: Li, Jinhuan, Shou, Jia, Guo, Ya, Tang, Yuanxiao, Wu, Yonghu, Jia, Zhilian, Zhai, Yanan, Chen, Zhifeng, Xu, Quan, Wu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524425/
https://ncbi.nlm.nih.gov/pubmed/25757625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjv016
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