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Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection
BACKGROUND: CTCF is a key insulator-binding protein, and mammalian genomes contain numerous CTCF sites, many of which are organized in tandem. RESULTS: Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and pr...
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| Publicado no: | Genome Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7087399/ https://ncbi.nlm.nih.gov/pubmed/32293525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01984-7 |
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