An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis

CTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of mammalian genomes. Previous studies have mainly focused on the roles of the canonical CTCF isoform. Here, we explore the functions of an alte...

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Udgivet i:Nat Commun
Main Authors: Li, Jiao, Huang, Kaimeng, Hu, Gongcheng, Babarinde, Isaac A., Li, Yaoyi, Dong, Xiaotao, Chen, Yu-Sheng, Shang, Liping, Guo, Wenjing, Wang, Junwei, Chen, Zhaoming, Hutchins, Andrew P., Yang, Yun-Gui, Yao, Hongjie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6449404/
https://ncbi.nlm.nih.gov/pubmed/30948729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08949-w
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