Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

[Image: see text] Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic drivers, and tumors harboring these lesions are some of the most difficult to treat. Although covalent small molecules against KRAS(G12C) have shown promising efficacy against lung cancers, traditiona...

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מידע ביבליוגרפי
הוצא לאור ב:ACS Cent Sci
Main Authors: Lim, Shuhui, Khoo, Regina, Juang, Yu-Chi, Gopal, Pooja, Zhang, Huibin, Yeo, Constance, Peh, Khong Ming, Teo, Jinkai, Ng, Simon, Henry, Brian, Partridge, Anthony W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2020
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908030/
https://ncbi.nlm.nih.gov/pubmed/33655066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01337
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