Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

[Image: see text] Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic drivers, and tumors harboring these lesions are some of the most difficult to treat. Although covalent small molecules against KRAS(G12C) have shown promising efficacy against lung cancers, traditiona...

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Publicat a:ACS Cent Sci
Autors principals: Lim, Shuhui, Khoo, Regina, Juang, Yu-Chi, Gopal, Pooja, Zhang, Huibin, Yeo, Constance, Peh, Khong Ming, Teo, Jinkai, Ng, Simon, Henry, Brian, Partridge, Anthony W.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908030/
https://ncbi.nlm.nih.gov/pubmed/33655066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01337
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