bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer new ways to address disease through tackling challenging targets and with greater potency, efficacy, and specificity over traditional approaches. However, identification of high-affinity ligands to serve as PROTAC...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lim, Shuhui, Khoo, Regina, Peh, Khong Ming, Teo, Jinkai, Chang, Shih Chieh, Ng, Simon, Beilhartz, Greg L., Melnyk, Roman A., Johannes, Charles W., Brown, Christopher J., Lane, David P., Henry, Brian, Partridge, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084165/
https://ncbi.nlm.nih.gov/pubmed/32123106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920251117
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