Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States

[Image: see text] Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic drivers, and tumors harboring these lesions are some of the most difficult to treat. Although covalent small molecules against KRAS(G12C) have shown promising efficacy against lung cancers, traditiona...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Lim, Shuhui, Khoo, Regina, Juang, Yu-Chi, Gopal, Pooja, Zhang, Huibin, Yeo, Constance, Peh, Khong Ming, Teo, Jinkai, Ng, Simon, Henry, Brian, Partridge, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908030/
https://ncbi.nlm.nih.gov/pubmed/33655066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01337
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados