bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer new ways to address disease through tackling challenging targets and with greater potency, efficacy, and specificity over traditional approaches. However, identification of high-affinity ligands to serve as PROTAC...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Lim, Shuhui, Khoo, Regina, Peh, Khong Ming, Teo, Jinkai, Chang, Shih Chieh, Ng, Simon, Beilhartz, Greg L., Melnyk, Roman A., Johannes, Charles W., Brown, Christopher J., Lane, David P., Henry, Brian, Partridge, Anthony W.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084165/
https://ncbi.nlm.nih.gov/pubmed/32123106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920251117
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