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Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma
BACKGROUND: The sensitivity of myelocytomatosis oncogene (MYC) amplified medulloblastoma to class I histone deacetylase (HDAC) inhibition has been shown previously; however, understanding the underlying molecular mechanism is crucial for selection of effective HDAC inhibitors for clinical use. The a...
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| Veröffentlicht in: | Neuro Oncol |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906057/ https://ncbi.nlm.nih.gov/pubmed/32822486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa191 |
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