Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation(1). Aberrant ferroportin activity can lead to diseases of ir...

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Udgivet i:Nature
Main Authors: Billesbølle, Christian B., Azumaya, Caleigh M., Kretsch, Rachael C., Powers, Alexander S., Gonen, Shane, Schneider, Simon, Arvedson, Tara, Dror, Ron O., Cheng, Yifan, Manglik, Aashish
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906036/
https://ncbi.nlm.nih.gov/pubmed/32814342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2668-z
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