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Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation(1). Aberrant ferroportin activity can lead to diseases of ir...
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| Vydáno v: | Nature |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906036/ https://ncbi.nlm.nih.gov/pubmed/32814342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2668-z |
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