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Biosynthesis of Oxetanocin-A Includes a B(12)-dependent Radical SAM Enzyme Able to Catalyze both Oxidative Ring Contraction and the Demethylation of SAM
Oxetanocin-A is an antitumor, antiviral, and antibacterial nucleoside. It is biosynthesized via the oxidative ring contraction of a purine nucleoside co-opted from primary metabolism. This reaction is catalyzed by a B(12)-dependent radical S-adenosyl-L-methionine (SAM) enzyme, OxsB, and a phosphohyd...
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| Yayımlandı: | Biochemistry |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7904626/ https://ncbi.nlm.nih.gov/pubmed/33560833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00915 |
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