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An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis

HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few have been both biochemically and structurally...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bridwell-Rabb, Jennifer, Kang, Gyunghoon, Zhong, Aoshu, Liu, Hung-wen, Drennan, Catherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137760/
https://ncbi.nlm.nih.gov/pubmed/27849620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613610113
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