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A B(12)-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis
Oxetanocin-A (OXT-A, 1) is a potent antitumor, antiviral, and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne, Bacillus megaterium gene cluster that contains four genes, oxsA, oxsB, oxrA, and oxrB. Here, we show that the oxsA and oxsB genes are both required for the...
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| Published in: | Nature |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5398914/ https://ncbi.nlm.nih.gov/pubmed/28346939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21689 |
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