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Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we revi...

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Bibliografische gegevens
Gepubliceerd in:Curr Opin Struct Biol
Hoofdauteurs: Bandarian, Vahe, Drennan, Catherine L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753066/
https://ncbi.nlm.nih.gov/pubmed/26643180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2015.11.005
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