Validated MALDI-TOF-MS method for anthrax lethal factor provides early diagnosis and evaluation of therapeutics

Anthrax lethal factor (LF) is a zinc-dependent endoprotease and a critical virulence factor for Bacillus anthracis, the causative agent of anthrax. The mass spectrometry (MS) method for total-LF quantification includes three steps; 1) LF specific antibody capture/concentration, 2) LF-specific hydrol...

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Udgivet i:Anal Biochem
Main Authors: Gallegos-Candela, Maribel, Boyer, Anne E., Woolfitt, Adrian R., Brumlow, Judy, Lins, Renato C., Quinn, Conrad P., Hoffmaster, Alex R., Meister, Gabriel, Barr, John R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904043/
https://ncbi.nlm.nih.gov/pubmed/29224733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2017.12.007
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