Discovery of O-Linked Carbohydrate on HIV-1 Envelope and Its Role in Shielding against One Category of Broadly Neutralizing Antibodies

Approximately 50% of the mass of the Envelope (Env) glycoprotein surface subunit (gp120) of human immunodeficiency virus type 1 (HIV-1) is composed of N-linked carbohydrate. Until now, the dogma has been that HIV-1 lacks O-linked carbohydrate on Env. Here we show that a subset of patient-derived HIV...

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Publicat a:Cell Rep
Autors principals: Silver, Zachary A., Antonopoulos, Aristotelis, Haslam, Stuart M., Dell, Anne, Dickinson, Gordon M., Seaman, Michael S., Desrosiers, Ronald C.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904042/
https://ncbi.nlm.nih.gov/pubmed/32049016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.056
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