Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To understand the interplay between glycan holes and neutralization...

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Publicat a:Cell Rep
Autors principals: Wagh, Kshitij, Kreider, Edward F., Li, Yingying, Barbian, Hannah J., Learn, Gerald H., Giorgi, Elena, Hraber, Peter T., Decker, Timothy G., Smith, Andrew G., Gondim, Marcos V., Gillis, Lindsey, Wandzilak, Jamie, Chuang, Gwo-Yu, Rawi, Reda, Cai, Fangping, Pellegrino, Pierre, Williams, Ian, Overbaugh, Julie, Gao, Feng, Kwong, Peter D., Haynes, Barton F., Shaw, George M., Borrow, Persephone, Seaman, Michael S., Hahn, Beatrice H., Korber, Bette
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426304/
https://ncbi.nlm.nih.gov/pubmed/30355496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.087
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