Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related bNAbs with up to 62% neutralization breadth from an HIV-infected donor. SF12 recognized a glycan-dominated epitope on Env’s silent face and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Immunity
Egile Nagusiak: Schoofs, Till, Barnes, Christopher O., Suh-Toma, Nina, Golijanin, Jovana, Schommers, Philipp, Gruell, Henning, West, Anthony P., Bach, Franziska, Lee, Yu Erica, Nogueira, Lilian, Georgiev, Ivelin S., Bailer, Robert T., Czartoski, Julie, Mascola, John R., Seaman, Michael S., McElrath, M. Juliana, Doria-Rose, Nicole A., Klein, Florian, Nussenzweig, Michel C., Bjorkman, Pamela J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591006/
https://ncbi.nlm.nih.gov/pubmed/31126879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.04.014
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