A Neutralizing Antibody Recognizing Primarily N-linked Glycan Targets the Silent Face of the HIV Envelope

Virtually the entire surface of the HIV-1-envelope trimer is recognized by neutralizing antibodies, except for a highly glycosylated region at the center of the “silent face” on the gp120 subunit. From an HIV-1-infected donor, #74, we identified antibody VRC-PG05, which neutralized 27% of HIV-1 stra...

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Publicado no:Immunity
Main Authors: Zhou, Tongqing, Zheng, Anqi, Baxa, Ulrich, Chuang, Gwo-Yu, Georgiev, Ivelin S., Kong, Rui, O’Dell, Sijy, Shahzad-ul-Hussan, Syed, Shen, Chen-Hsiang, Tsybovsky, Yaroslav, Bailer, Robert T., Gift, Syna K., Louder, Mark K., McKee, Krisha, Rawi, Reda, Stevenson, Catherine H., Stewart-Jones, Guillaume B. E., Taft, Justin D., Waltari, Eric, Yang, Yongping, Zhang, Baoshan, Shivatare, Sachin S., Shivatare, Vidya S., Lee, Chang-Chun D., Wu, Chung-Yi, Mullikin, James C., Bewley, Carole A., Burton, Dennis R., Polonis, Victoria R., Shapiro, Lawrence, Wong, Chi-Huey, Mascola, John R., Kwong, Peter D., Wu, Xueling
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421865/
https://ncbi.nlm.nih.gov/pubmed/29548671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.02.013
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