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Abundance of P-glycoprotein and other drug transporters at the human blood-brain barrier in Alzheimer’s Disease: a quantitative targeted proteomic study
The human blood-brain barrier (BBB) transporter P-glycoprotein (P-gp) can efflux amyloid-β out of the central nervous system. Amyloid-β is thought to be the causative agent for Alzheimer’s Disease (AD). Using PET imaging, we have shown that BBB P-gp activity is reduced in AD, as quantified by the in...
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| Опубликовано в: : | Clin Pharmacol Ther |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902298/ https://ncbi.nlm.nih.gov/pubmed/32885413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2035 |
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