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Abundance of P-glycoprotein and other drug transporters at the human blood-brain barrier in Alzheimer’s Disease: a quantitative targeted proteomic study

The human blood-brain barrier (BBB) transporter P-glycoprotein (P-gp) can efflux amyloid-β out of the central nervous system. Amyloid-β is thought to be the causative agent for Alzheimer’s Disease (AD). Using PET imaging, we have shown that BBB P-gp activity is reduced in AD, as quantified by the in...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Storelli, Flavia, Billington, Sarah, Kumar, Aditya R., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902298/
https://ncbi.nlm.nih.gov/pubmed/32885413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2035
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