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Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
Tumor-specific CD8(+)T cells are exposed to persistent antigenic stimulation which induces a dysfunctional state called “exhaustion.” Though functioning to limit damage caused by immune response, T cell exhaustion leads to attenuated effector function whereby cytotoxic CD8(+)T cells fail to control...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902023/ https://ncbi.nlm.nih.gov/pubmed/33633741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.622509 |
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