A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

The biosafety level 3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research. Here, we report a trans-complementation system that produces single-round infectious SARS-CoV-2 that recapitulates authentic viral replication. We demonstra...

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Publicado no:Cell
Main Authors: Zhang, Xianwen, Liu, Yang, Liu, Jianying, Bailey, Adam L., Plante, Kenneth S., Plante, Jessica A., Zou, Jing, Xia, Hongjie, Bopp, Nathen E., Aguilar, Patricia V., Ren, Ping, Menachery, Vineet D., Diamond, Michael S., Weaver, Scott C., Xie, Xuping, Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901297/
https://ncbi.nlm.nih.gov/pubmed/33691138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.02.044
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