A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

The biosafety level 3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research. Here, we report a trans-complementation system that produces single-round infectious SARS-CoV-2 that recapitulates authentic viral replication. We demonstra...

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Publicat a:Cell
Autors principals: Zhang, Xianwen, Liu, Yang, Liu, Jianying, Bailey, Adam L., Plante, Kenneth S., Plante, Jessica A., Zou, Jing, Xia, Hongjie, Bopp, Nathen E., Aguilar, Patricia V., Ren, Ping, Menachery, Vineet D., Diamond, Michael S., Weaver, Scott C., Xie, Xuping, Shi, Pei-Yong
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Inc. 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901297/
https://ncbi.nlm.nih.gov/pubmed/33691138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.02.044
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