Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

BACKGROUND: Small-conductance Ca(2+)-activated K(+) (K(Ca)2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the importance of the K(Ca)2 current—and thereby...

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Pubblicato in:Front Physiol
Autori principali: Fenner, Merle Friederike, Gatta, Giulia, Sattler, Stefan, Kuiper, Marion, Hesselkilde, Eva Melis, Adler, Ditte M. T., Smerup, Morten, Schotten, Ulrich, Sørensen, Ulrik, Diness, Jonas Goldin, Jespersen, Thomas, Verheule, Sander, Van Hunnik, Arne, Buhl, Rikke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900437/
https://ncbi.nlm.nih.gov/pubmed/33633584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.614483
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