Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

BACKGROUND: Small-conductance Ca(2+)-activated K(+) (K(Ca)2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the importance of the K(Ca)2 current—and thereby...

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Publicado no:Front Physiol
Main Authors: Fenner, Merle Friederike, Gatta, Giulia, Sattler, Stefan, Kuiper, Marion, Hesselkilde, Eva Melis, Adler, Ditte M. T., Smerup, Morten, Schotten, Ulrich, Sørensen, Ulrik, Diness, Jonas Goldin, Jespersen, Thomas, Verheule, Sander, Van Hunnik, Arne, Buhl, Rikke
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900437/
https://ncbi.nlm.nih.gov/pubmed/33633584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.614483
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