Effect of selective I (K,ACh) inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation

BACKGROUND AND PURPOSE: Inhibition of the G‐protein gated ACh‐activated inward rectifier potassium current, I (K,ACh) may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti‐arrhythmic and electrophysiological properties of a novel putatively potent...

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Publicado no:Br J Pharmacol
Main Authors: Fenner, Merle Friederike, Carstensen, Helena, Dalgas Nissen, Sarah, Melis Hesselkilde, Eva, Scott Lunddahl, Christine, Adler Hess Jensen, Maja, Loft‐Andersen, Ameli Victoria, Sattler, Stefan Michael, Platonov, Pyotr, El‐Haou, Said, Jackson, Claire, Tang, Raymond, Kirby, Robert, Ford, John, Schotten, Ulrich, Milnes, James, Svane Sørensen, Ulrik, Jespersen, Thomas, Buhl, Rikke
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393200/
https://ncbi.nlm.nih.gov/pubmed/32436234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15100
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