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Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

BACKGROUND: Small-conductance Ca(2+)-activated K(+) (K(Ca)2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the importance of the K(Ca)2 current—and thereby...

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Bibliografiske detaljer
Udgivet i:Front Physiol
Main Authors: Fenner, Merle Friederike, Gatta, Giulia, Sattler, Stefan, Kuiper, Marion, Hesselkilde, Eva Melis, Adler, Ditte M. T., Smerup, Morten, Schotten, Ulrich, Sørensen, Ulrik, Diness, Jonas Goldin, Jespersen, Thomas, Verheule, Sander, Van Hunnik, Arne, Buhl, Rikke
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900437/
https://ncbi.nlm.nih.gov/pubmed/33633584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.614483
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