Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first show up-regulation of REV-ERBα/Rev-erbα in brain tissues from patients with epilepsy and a m...

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Publicat a:Nat Commun
Autors principals: Zhang, Tianpeng, Yu, Fangjun, Xu, Haiman, Chen, Min, Chen, Xun, Guo, Lianxia, Zhou, Cui, Xu, Yuting, Wang, Fei, Yu, Jiandong, Wu, Baojian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900242/
https://ncbi.nlm.nih.gov/pubmed/33619249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21477-w
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