Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity

Systemic insulin sensitivity shows diurnal rhythm with a peak at wakening(1,2). The molecular mechanism underlying such a temporal pattern is unclear. Here we demonstrate that nuclear receptors Rev-erbα/β in the GABAergic neurons in the suprachiasmatic nucleus (SCN(GABA)) control the diurnal rhythm...

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Udgivet i:Nature
Main Authors: Ding, Guolian, Li, Xin, Hou, Xinguo, Zhou, Wenjun, Gong, Yingyun, Liu, Fuqiang, He, Yanlin, Song, Jia, Wang, Jing, Basil, Paul, Li, Wenbo, Qian, Sichong, Saha, Pradip, Wang, Jinbang, Cui, Chen, Yang, Tingting, Zou, Kexin, Han, Younghun, Amos, Christopher I., Xu, Yong, Chen, Li, Sun, Zheng
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085086/
https://ncbi.nlm.nih.gov/pubmed/33762728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03358-w
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