REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Griffin, Percy, Sheehan, Patrick W, Dimitry, Julie M, Guo, Chun, Kanan, Michael F, Lee, Jiyeon, Zhang, Jinsong, Musiek, Erik S
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728439/
https://ncbi.nlm.nih.gov/pubmed/33258449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58765
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky