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REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7728439/ https://ncbi.nlm.nih.gov/pubmed/33258449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58765 |
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