REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression...

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Bibliographic Details
Published in:eLife
Main Authors: Griffin, Percy, Sheehan, Patrick W, Dimitry, Julie M, Guo, Chun, Kanan, Michael F, Lee, Jiyeon, Zhang, Jinsong, Musiek, Erik S
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728439/
https://ncbi.nlm.nih.gov/pubmed/33258449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58765
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