Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

To design potentially more effective therapies, we need to further understand the mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian regulation of epileptic seizures. We first show up-regulation of REV-ERBα/Rev-erbα in brain tissues from patients with epilepsy and a m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Zhang, Tianpeng, Yu, Fangjun, Xu, Haiman, Chen, Min, Chen, Xun, Guo, Lianxia, Zhou, Cui, Xu, Yuting, Wang, Fei, Yu, Jiandong, Wu, Baojian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900242/
https://ncbi.nlm.nih.gov/pubmed/33619249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21477-w
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