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The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition

The intestinal exporter MRP2 plays an important role in disposition and elimination of a wide range of drugs. Here, we aimed to clarify the impact of circadian clock on intestinal MRP2, and to determine the molecular mechanisms for generation of diurnal MRP2 expression. Methods: The regulatory effec...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Theranostics
Egile Nagusiak: Yu, Fangjun, Zhang, Tianpeng, Zhou, Cui, Xu, Haiman, Guo, Lianxia, Chen, Min, Wu, Baojian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ivyspring International Publisher 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568180/
https://ncbi.nlm.nih.gov/pubmed/31244920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.33395
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