Nephron-Specific Deletion of Circadian Clock Gene Bmal1 Alters the Plasma and Renal Metabolome and Impairs Drug Disposition

The circadian clock controls a wide variety of metabolic and homeostatic processes in a number of tissues, including the kidney. However, the role of the renal circadian clocks remains largely unknown. To address this question, we performed a combined functional, transcriptomic, and metabolomic anal...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Nikolaeva, Svetlana, Ansermet, Camille, Centeno, Gabriel, Pradervand, Sylvain, Bize, Vincent, Mordasini, David, Henry, Hugues, Koesters, Robert, Maillard, Marc, Bonny, Olivier, Tokonami, Natsuko, Firsov, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042670/
https://ncbi.nlm.nih.gov/pubmed/27056296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015091055
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