Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the disability. Dystrophin replacement strategies are h...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Ziemba, Michael, Barkhouse, Molly, Uaesoontrachoon, Kitipong, Giri, Mamta, Hathout, Yetrib, Dang, Utkarsh J., Gordish-Dressman, Heather, Nagaraju, Kanneboyina, Hoffman, Eric P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899329/
https://ncbi.nlm.nih.gov/pubmed/33617542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246507
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