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Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the disability. Dystrophin replacement strategies are h...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ziemba, Michael, Barkhouse, Molly, Uaesoontrachoon, Kitipong, Giri, Mamta, Hathout, Yetrib, Dang, Utkarsh J., Gordish-Dressman, Heather, Nagaraju, Kanneboyina, Hoffman, Eric P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899329/
https://ncbi.nlm.nih.gov/pubmed/33617542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246507
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