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Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the disability. Dystrophin replacement strategies are h...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7899329/ https://ncbi.nlm.nih.gov/pubmed/33617542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246507 |
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