Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Duchenne muscular dystrophy is initiated by dystrophin deficiency, but downstream pathophysiological pathways such as membrane instability, NFĸB activation, mitochondrial dysfunction, and induction of TGFβ fibrosis pathways are thought to drive the disability. Dystrophin replacement strategies are h...

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Foilsithe in:PLoS One
Main Authors: Ziemba, Michael, Barkhouse, Molly, Uaesoontrachoon, Kitipong, Giri, Mamta, Hathout, Yetrib, Dang, Utkarsh J., Gordish-Dressman, Heather, Nagaraju, Kanneboyina, Hoffman, Eric P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899329/
https://ncbi.nlm.nih.gov/pubmed/33617542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246507
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