Glucocorticoid-Treated Mice Are an Inappropriate Positive Control for Long-Term Preclinical Studies in the mdx Mouse

BACKGROUND: Dmd(mdx) (mdx) mice are used as a genetic and biochemical model of dystrophin deficiency. The long-term consequences of glucocorticoid (GC) treatment on dystrophin-deficient skeletal and heart muscle are not yet known. Here we used systematic phenotyping to assess the long-term consequen...

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Hauptverfasser: Sali, Arpana, Guerron, Alfredo D., Gordish-Dressman, Heather, Spurney, Christopher F., Iantorno, Micaela, Hoffman, Eric P., Nagaraju, Kanneboyina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317932/
https://ncbi.nlm.nih.gov/pubmed/22509280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034204
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