The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

BACKGROUND: In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction...

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Autori principali: Sali, Arpana, Many, Gina M., Gordish-Dressman, Heather, van der Meulen, Jack H., Phadke, Aditi, Spurney, Christopher F., Cnaan, Avital, Hoffman, Eric P., Nagaraju, Kanneboyina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699610/
https://ncbi.nlm.nih.gov/pubmed/23843959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066617
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