The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

BACKGROUND: In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction...

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Bibliografiska uppgifter
Huvudupphovsmän: Sali, Arpana, Many, Gina M., Gordish-Dressman, Heather, van der Meulen, Jack H., Phadke, Aditi, Spurney, Christopher F., Cnaan, Avital, Hoffman, Eric P., Nagaraju, Kanneboyina
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699610/
https://ncbi.nlm.nih.gov/pubmed/23843959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066617
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