The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

BACKGROUND: In Duchenne muscular dystrophy (DMD), loss of the membrane stabilizing protein dystrophin results in myofiber damage. Microinjury to dystrophic myofibers also causes secondary imbalances in sarcolemmic ion permeability and resting membrane potential, which modifies excitation-contraction...

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Main Authors: Sali, Arpana, Many, Gina M., Gordish-Dressman, Heather, van der Meulen, Jack H., Phadke, Aditi, Spurney, Christopher F., Cnaan, Avital, Hoffman, Eric P., Nagaraju, Kanneboyina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699610/
https://ncbi.nlm.nih.gov/pubmed/23843959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066617
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