The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new urinary biomarkers are needed to monitor this...

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Publicado en:Toxicol Rep
Autores principales: Zhang, Aiping, Uaesoontrachoon, Kitipong, Shaughnessy, Conner, Das, Jharna R., Rayavarapu, Sree, Brown, Kristy J., Ray, Patricio E., Nagaraju, Kanneboyina, van den Anker, John N., Hoffman, Eric P., Hathout, Yetrib
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512206/
https://ncbi.nlm.nih.gov/pubmed/26213685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2015.05.008
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