The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new urinary biomarkers are needed to monitor this...

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Udgivet i:Toxicol Rep
Main Authors: Zhang, Aiping, Uaesoontrachoon, Kitipong, Shaughnessy, Conner, Das, Jharna R., Rayavarapu, Sree, Brown, Kristy J., Ray, Patricio E., Nagaraju, Kanneboyina, van den Anker, John N., Hoffman, Eric P., Hathout, Yetrib
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512206/
https://ncbi.nlm.nih.gov/pubmed/26213685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2015.05.008
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