The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

Phosphorodiamidate morpholino oligonucleotides (PMO) are used as a promising exon-skipping gene therapy for Duchenne muscular dystrophy (DMD). One potential complication of high dose PMO therapy is its transient accumulation in the kidneys. Therefore new urinary biomarkers are needed to monitor this...

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Veröffentlicht in:Toxicol Rep
Hauptverfasser: Zhang, Aiping, Uaesoontrachoon, Kitipong, Shaughnessy, Conner, Das, Jharna R., Rayavarapu, Sree, Brown, Kristy J., Ray, Patricio E., Nagaraju, Kanneboyina, van den Anker, John N., Hoffman, Eric P., Hathout, Yetrib
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512206/
https://ncbi.nlm.nih.gov/pubmed/26213685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxrep.2015.05.008
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