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Prebiotically Plausible RNA Activation Compatible with Ribozyme‐Catalyzed Ligation

RNA‐catalyzed RNA ligation is widely believed to be a key reaction for primordial biology. However, since typical chemical routes towards activating RNA substrates are incompatible with ribozyme catalysis, it remains unclear how prebiotic systems generated and sustained pools of activated building b...

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Bibliographische Detailangaben
Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Song, Emilie Yeonwha, Jiménez, Eddy Ivanhoe, Lin, Huacan, Le Vay, Kristian, Krishnamurthy, Ramanarayanan, Mutschler, Hannes
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898671/
https://ncbi.nlm.nih.gov/pubmed/33128282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202010918
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