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Generation of Sex-Reversed Female Clonal Mice via CRISPR-Cas9-Mediated Y Chromosome Deletion in Male Embryonic Stem Cells

Mice derived entirely from embryonic stem (ES) cells can be generated through tetraploid complementation. Although XY male ES cell lines are commonly used in this system, occasionally, monosomic XO female mice are produced through spontaneous Y chromosome loss. Here, we describe an efficient method...

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Dades bibliogràfiques
Publicat a:CRISPR J
Autors principals: Qin, Yiren, Wong, Bokey, Zhong, Liangwen, Geng, Fuqiang, Parada, Luis F., Wen, Duancheng
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc., publishers 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898403/
https://ncbi.nlm.nih.gov/pubmed/33567216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/crispr.2020.0074
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