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Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology
BACKGROUND: Chromosomal translocations are a hallmark of cancer cells and give rise to fusion oncogenes. To gain insight into the mechanisms governing tumorigenesis, adequate model cell lines are required. RESULTS: We employ the versatile CRISPR/Cas system to engineer cell lines in which chromosomal...
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| Published in: | BMC Genomics |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027121/ https://ncbi.nlm.nih.gov/pubmed/27640184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3084-5 |
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