Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair

Chromosomal rearrangements encoding oncogenic fusion proteins are found in a wide variety of malignancies. The use of programmable nucleases to generate specific double-strand breaks in endogenous loci, followed by non-homologous end joining DNA repair, has allowed several of these translocations to...

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Detaylı Bibliyografya
Yayımlandı:J Pathol
Asıl Yazarlar: Spraggon, Lee, Martelotto, Luciano G, Hmeljak, Julija, Hitchman, Tyler D, Wang, Jiang, Wang, Lu, Slotkin, Emily K, Fan, Pang-Dian, Reis-Filho, Jorge S, Ladanyi, Marc
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5397343/
https://ncbi.nlm.nih.gov/pubmed/28188619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4883
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